A chelating nucleophile plays a starring role: 1,8-naphthyridine-catalyzed polycomponent α,α-difluorination of acid chlorides.
نویسندگان
چکیده
A dually activated ketene enolate, generated from an acid chloride, the unusual chelating nucleophile (1,8-naphthyridine), and a Lewis acid, reacts to afford a host of α,α-difluorinated products in the presence of a benchtop-stable fluorinating agent (Selectfluor). The use of this method to synthesize otherwise difficult to make products is highlighted along with computational and spectroscopic support for the proposed chelate.
منابع مشابه
Tricomponent catalytic α,α-difluorination of acid chlorides.
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ورودعنوان ژورنال:
- The Journal of organic chemistry
دوره 79 20 شماره
صفحات -
تاریخ انتشار 2014